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One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37
Ylikomi, T
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Bacteria can decompose peptides and must be sterilized before storage
Ltd) and retatrutide are the most advanced and are in Phase III clinical trials (Table 2)
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