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Cryptosporidium expresses its glutathione reductase (GR) gene to recycle GSH throughout its asexual and sexual life cycle, yet two glutathione S-transferases (GSTs), enzymes that post-translationally modify proteins with GSH, appear to be expressed exclusively in female (cgd7_4780) and male (cgd8_2970) parasites 44

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For example, activation of the limbic and paralimbic systems, which are responsible for behavioral and emotional responses, are thought to contribute to distress signaling and complications of tinnitus, such as cognitive, mood, and sleep disorders, in some individuals