And the first GLP-1 for weight loss was approved in 2014, which suddenly seems like a long time ago
I started experiencing appetite suppression after about 4 weeks, but you should notice a significant difference at around the 12 to 16 week-mark
If youre searching for this comparison, its worth knowing that Saxenda has been discontinued by Novo Nordisk
For researchers choosing between the two most potent compounds in this class, retatrutide currently shows a 1.52 percentage-point weight-loss advantage over tirzepatide at comparable durations, but tirzepatide carries substantially more Phase 3 evidence and a confirmed MHRA authorisation [1][2]
The GLP-1R/GIPR dual-agonist tirzepatide has demonstrated a remarkable 23% body weight reduction in individuals with obesity over 72 weeks, eclipsing the average result achieved by certain bariatric surgery [78]
Skipping ahead to higher doses to lose weight faster is one of the strongest predictors of severe muscle loss in clinical observation