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GLP-1 improves insulin sensitivity, thereby reducing systemic inflammatory stress

Mechanisms of action and therapeutic application of GLP-1. Cell Metabolism , 2021.

These outcomes are clinically significant, as even modest weight loss can lead to meaningful improvements in metabolic health

IGF-1 LR3 has a higher binding affinity for IGF-1R and reduced IGFBP binding compared to native IGF-1, meaning free tissue exposure is greater for equivalent doses, which amplifies the theoretical risk

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