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Moreover, Kim et al

Reduces the appearance of dark spots and discoloration

Green, MD , professor of medicine at Duke University School of Medicine: While losing weight, our brain has kind of a weight-happy place and when we move away from that, our brain is unhappy and alters hormone levels to counteract it, so our body makes it more difficult to continue to lose weight once weve started losing and unfortunately, it tends to make us regain the weight back. This is supported by studies showing that the hunger hormone ghrelin increases with weight loss, and leptin which helps prevent hunger and regulate energy balance decreases with weight loss [18]

The World Health Organization's December 2025 guidelines emphasized the importance of resistance training to protect muscle mass during GLP-1 therapy, acknowledging this as a limitation of current treatment approaches [49]

BMI is measured at the time GLP-1 therapy is initiated not at the time of the prior authorization submission

Researchers estimate that anywhere from 25% to 40% of total weight lost on GLP-1 drugs may come from lean mass, which includes skeletal muscle