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Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )

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DFO is a clinically used iron chelator derived from streptomyces polymyxa and is a hexadentate complex that forms a 1:1 Fe 3+ /DFO complex at physiological PH

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