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Eli Lilly developed tirzepatide for type 2 diabetes (Mounjaro, FDA-approved 2022) and later for chronic weight management (Zepbound, 2023)

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Therefore, the present study aimed to provide experimental evidence for the combined application of GLP-1R antagonists and ICIs in CRC, offering novel strategies for optimizing combination therapies for this disease in the future

The choice between these options depends on injury severity, budget, access to qualified providers, and individual circumstances