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This could be attributed to the different mechanisms of action of these two drugs
Thus far, the binding poses of two full-length peptide-bound, active GLP-1R structures 3,4 and an active-like structure with a truncated peptide agonist (peptide 5) 12 have been detailed, as well as variable ligand-dependent ECD receptor conformations
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Pharmacogenet Genomics 20(11):708715 Yeo EJ, Wagner C (1994) Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
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