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For patients with severe obesity (BMI 40 or 35 with obesity-related complications), referral for evaluation of bariatric surgery may be appropriate according to American Society for Metabolic and Bariatric Surgery guidelines
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Tirzepatide, a dual GIP/GLP-1 receptor agonist, is also available in oral and sublingual compounded formats
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System X c is driven by concentrations gradient from extracellular Cys and intracellular Glu, transporting Cys and Glu in a 1:1 ratio (Figure 1)
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