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Association of incretin-based therapies with hepatobiliary disorders among patients with type 2 diabetes: a case series from the FDA adverse event reporting system
Water retention comes from #3 and #4
Side effects happened more often when people went up in their dose or were at a higher dosebut even then, the impact tended to be in that mild to moderate range
Your tolerance to side effects also shapes dosing decisions
Untested formulations Semaglutide and tirzepatide are FDA-approved as injectables (an oral tablet version of semaglutide is also approved), but the formulations some drug compounding pharmacies are selling in the form of sublingual drops or dissolving tablets have never been studied in clinical trials
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