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Phosphatidylethanolamines (PEs) containing elongation products such as arachidonic acid (C20:4) or adrenic acid (C22:4) primarily promote lipid oxidation processes involved in cellular iron dependent death, making them potential targets for regulating iron dependent death

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This data demonstrated that Trx would perturb only the first flavin reoxidation phase, but it was not known definitively whether the disulfides of Trx interact directly with the C154-C159 pair or with the C596-C597 pair

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