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GSTM1 null individuals displayed lower levels of SFN-CG in the urine suggesting that they may metabolize SFN less efficiently

However, in the posterior cortex, CAT activity was reduced in the VPA+LipRSV group compared to the VPA group, indicating that LipRSV treatment may have negatively modulated the enzymes expression or activity, either by attenuating oxidative stress and thus reducing enzymatic defense needs, or through a possible pro-oxidant effect dependent on the region and experimental conditions

Yamamoto, T., Azechi, H

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Most people start noticing improvements during the infusion itself