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These include: Large disc extrusions or sequestered fragments requiring surgical intervention Severe spinal stenosis with significant canal narrowing Bone spurs (osteophytes) compressing nerve structures Advanced degenerative disc disease with complete disc height loss Spondylolisthesis (vertebral slippage) beyond grade 1 Cauda equina syndrome (medical emergency requiring immediate surgery) Users with these conditions typically report minimal improvement from peptide therapy alone
2018;3:CD004655
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Peptides don't directly provide differentiation signals but create environment supporting natural differentiation processes
5 Journal of Endocrinology & Metabolism (2013)Safety & tolerability of AOD-9604 in humans (no IGF-1 increase
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