Cardio supports overall health but isn't required for weight loss
It has been posited to function similarly to Growth Hormone Releasing Peptides (GHRPs) and to potentially emulate the natural hunger hormone, ghrelin, particularly its potential to stimulate the release of hGH from the cells in the anterior pituitary gland
Suleiman et al., 2021)
These studies suggest that GLP-1 and its receptor play a role in the pathophysiology of congenital hyperinsulinism and that targeting the GLP-1 receptor may be an effective treatment approach for this condition ( ATP hyperinsulinism and decreases glucose infusion rate requirements in infants with K ATP hyperinsulinism (3335)
Additionally, agents capable of positively modulating more than one peptide hormone receptor simultaneously, such as tirzepatide or the recently characterised GL-0001 peptide, could offer an even more exciting avenue to help realise the potential of gut-derived hormones to treat bone disease
In broad terms the published literature associates the first branch more with metabolic and survival readouts and the second more with proliferative ones, but the separation is a tendency rather than a rule and depends heavily on cell background
