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Cancer 75(2 Suppl):645650 Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A, Stoppa-Lyonnet D, Benard J, Paillerets B B-d (1999a) Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France
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In a study of more than 240,000 people, heavier individuals were significantly more likely to form stones than lean ones.[3] The reason is biochemical: obesity and insulin resistance push the kidney to excrete more calcium, oxalate, and uric acid, and they make the urine more acidic close to a perfect recipe for stone crystals
These were averaged to generate a single data point (Fig
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