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A decrease in the fatty acid metabolite heptanoic acid was also observed, indicating an increased use of fatty acids as an alternative energy source, via -oxidation to acetyl-CoA and propionyl-CoA 85 .This use of fatty acids is further reinforced by elevated malonate levels in barren urchins, as malonate is converted to malonyl-CoA via the ATP-dependent enzyme acetyl-CoA carboxylase, the primary step in fatty acid synthesis 91

10.1002/wnan.1410 7 ChengX.XuH.-D.RanH.-H.LiangG.WuF.-G

Argelles, J

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Consistent with our recent results [5], Tan et al