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In animal studies, this drug not only directly activates GLP-1 receptors in the hypothalamus and brainstem but also indirectly modulates neuronal circuits in other regions involved in eating behavior, such as the lateral parabrachial nucleus

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Patients with lower BMI tend to quit more often

doi: 10.1111/j.1463-1326.2008.00992.x 91 KimDMChuSHKimSParkYWKimSS

Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations

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