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Apart from maintaining calcium channel homeostasis, GLP-1RAs also activate ATP-sensitive potassium channels to attenuate cardiac apoptosis and hypertrophy induced by pressure overload [166]
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Metformin is usually taken by mouth and has decades of use in type 2 diabetes care
6,8 Studies looking at higher doses, such as one comparing 12.5mg, 25mg, and 50mg, found a non-dose-dependent steady-state level maximum at the 25mg dose
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