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GLP-1 is a gut hormone your body naturally produces after eating

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Studies that met the following inclusion criteria were selected: 1) A study population consisting of NAFLD or NASH patients diagnosed with biopsy or other imaging methods, 2) adult participants, 3) GLP-1RA or TZD treatment as intervention group, 4) active or placebo control group, 5) at least 3 months of treatment duration, 6) liver biopsy-based, noninvasive technique-based, biological parameters, or anthropometric parameters as outcomes

They also found that ROS damage affected the nucleus of the sperm causing DNA damage which could be transmitted to the next generation and be responsible for increased disease susceptibility in offspring

After completion of the trial, a large subset of patients was observed for up to 10 additional years, with little additional exposure to pioglitazone