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Pediatrics 134 , e833e845 (2014)

It is notable for its ability to traverse the blood-brain barrier, enabling systemic and central nervous system effects ( 1, 8 )

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Lifestyle factors Sedentary behavior, which can increase during the initial weeks of semaglutide treatment when nausea and fatigue are most prominent, independently raises UTI risk

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They also lost more weight than participants assigned the placebo, and researchers say their weight loss was likely the reason for the other positive outcomes