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Avoid areas with visible veins, moles, or scar tissue, as these zones have more fragile vasculature

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Therefore, we found that acetaminophen was metabolized to AM404, which induces analgesia by directly inhibiting the excitatory synaptic transmission via TRPV1 receptors expressed on terminals of C-fibers in the spinal dorsal horn

Kamrava MM et al

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These may be mild or severe and can be treated with over-the-counter pain relievers