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In a mouse model of colitis induced by dextran sulfate sodium, genetically engineered EcN 1917 expressed high levels of schistosome immunoregulatory protein (Sj16) in the gastrointestinal tract, significantly improving the colitis symptoms in the mice 177
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In those cases, preservative-free sterile water for injection (without benzyl alcohol) is required
Meanwhile, the levels of IL-1, IL-6, and TNF- were significantly decreased, with the most significant down-regulation observed in the MN/GLP-1RAs@NPs-WYRGRL group (Fig
Dowling R
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