This expanded approval is based on results from the pivotal FLOW phase 3b clinical trial, which demonstrated that once-weekly semaglutide led to a statistically significant 24% reduction in the risk of kidney disease progression, kidney failure, and cardiovascular death compared to placebo, when added to standard care
Cardiovascular protection: what the SELECT trial revealed The SELECT trial changed how physicians think about semaglutide
So compared to Wegovy, compounded semaglutide can theoretically match the higher weight-loss dose without the insurance obstacle course
Mattioli 1885 Journals (2022)
Individuals with pre-existing gastrointestinal conditions such as inflammatory bowel disease (Crohn's disease or ulcerative colitis), irritable bowel syndrome, or small intestinal bacterial overgrowth (SIBO) should discuss probiotic selection with their healthcare provider, as certain strains may be more appropriate than others for specific conditions
The roles of GLP-1 with regard to actin dynamics in cardiovascular and neurodegenerative disease processes have not yet been well established