how long do the side effects of glp 1 last What to Expect After First Semaglutide GLP-1 Injection? GLP-1 Side Effect Management: Nutrition

Last Updated: October 26, 2025 QUICK ANSWER: The 3 most common side effects are: Nausea, diarrhea and constipation

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Gastrointestinal adverse events during follow-up were statistically significant ( Oral semaglutide has been studied in PIONEER 6 (designed as a non-inferiority trials), with a mean follow-up of 1.3 years and positive results for the primary endpoint: the MACE rate was reduced by 21% but did not achieve statistically significant differences

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The injection of semaglutide also slows the movement of food through the stomach, which may lead to weight loss and a decrease in appetite