Whenever youre activating something in the brain, we can expect that the brain and the GI tract may respond with nausea. GLP-1 medications also work in the gut by slowing down the digestion process, so food is in the stomach for a longer period of time
Michalon, A
Attaching a 16-carbon side chain (palmitic acid) to the peptide allowed the molecule to bind to the abundant blood protein albumin and keep it in circulation
Standard GLP-1 eligibility thresholds - based on the FDA-approved drug labeling for Wegovy and Zepbound, which guides how clinicians think about the category - generally include a BMI of 30 or higher (obese), or a BMI of 27 or higher with at least one weight-related comorbidity such as high blood pressure, high cholesterol, or type 2 diabetes
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