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Peer review Peer review information Nature Catalysis thanks Mattheos Koffas, Bengt Mannervik, Boas Pucker, Dingguo Xu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Most clinical practice guidance recommends sequential or monitored approaches rather than automatic combination

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Liver function tests to ensure glutathione therapy is not causing hepatic effects (though this is uncommon)

As part of the antioxidant defence system, GSH participates in conjugation reactions catalyzed by glutathione-S-transferases (GSTs), in the reduction of hydrogen peroxide (H O ) and lipid hydroperoxides (LOOH) catalyzed by glutathione peroxidases (Gpxs), and the reduction 2 2 of protein-disulfi des (PrSSG) catalyzed by glutaredoxins (Grxs)