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Antagonising glucagon receptors (GCGRs) with modified glucagon analogues, small molecules or antisense oligonucleotides has also been problematic because of the risk of hypoglycaemia and adverse effects on liver function, including steatosis and an increase in LDL-cholesterol

Metformin is usually the first-line treatment for Type 2 Diabetes due to its long-term safety and cost-effectiveness

Vitamin C enhances collagen production, improving skin elasticity and reducing the appearance of fine lines, while Vitamin E provides deep hydration and protection against environmental damage

After the initial treatment period, maintenance doses may be given less frequently

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Side Effects and Safety Reported Side Effects (Rare) Mild headache (transient, first dose) Slight injection site irritation Nausea (if dosed too high on empty stomach) Sleep quality changes (usually improvement) Safety Profile Non-hormonal doesn't suppress testosterone or disrupt hormonal systems No major contraindications known No overdose risk excess peptide is simply cleared Well-tolerated across diverse populations No organ toxicity safe for liver, kidney, heart Contraindications (Caution) Active cancer growth-promoting effects could theoretically benefit cancer (no direct evidence, but be cautious) Pregnancy insufficient human data Active infection at injection site standard sterile injection protocols apply Drug Interactions No known major interactions with common medications