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(January 2026)

Prescription medication requiring medical supervision Contraindicated in patients with personal or family history of medullary thyroid carcinoma or MEN2 Most common adverse events are gastrointestinal (nausea, diarrhea, vomiting) Dose escalation schedule important to minimize GI side effects Efficacy and Safety of the Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide in Patients With Type 2 Diabetes (SURPASS-1): A Double-Blind, Randomised, Phase 3 Trial , published in The Lancet (Rosenstock J et al., 2021

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Introduction Polycystic ovary syndrome (PCOS) is a common reproductive and endocrine disorder, affecting 5% to 20% of women of child-bearing age and accounting for approximately 75% of anovulatory infertility disorders

In addition, knockout of other autophagy-related genes, such as ULK1/2, ATG3, and ATG13, also significantly inhibited erastin-induced ferroptosis