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6 The Many Complications of Chronic Kidney Disease CKD is associated with a wide range of significant health complications, including 64 : Cardiovascular Disease Cardiovascular disease, particularly advanced cardiovascular disease, is associated with a significantly elevated risk of various cardiovascular problems, such as hypertension (high blood pressure), arterial calcification (calcium buildup in the arteries), heart failure, valvular disease (damaged heart valves), and atherosclerosis

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