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10.1038/s41589-020-0544-7 101 GuillonneauC.ChartonY.GinotY.-M.Fouquier-DHroulM.-V.BertrandM.LockhartB.et al (2003)
Holman, UKPDS Study Group: risk factors for renal dysfunction in type 2 diabetes: U.K
The compound continues working at the same dose over the study periods observed to date
Hypertension : Elevated blood pressure has been observed in certain cases, necessitating close monitoring
A 2023 review in Cells described these agents as promising therapies across cardiovascular, renal, neurodegenerative, and metabolic conditions, while noting that the relative contribution of direct cellular effects versus improved cardiometabolic regulation remains under investigation [4]
Supplemental Table 1)
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