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But they are worth noting

For weight loss, many patients find their sweet spot between 1.0 and 2.4 mg weekly, where appetite suppression is strong but side effects remain manageable

This variation can potentially affect how the medication works in your body

Both semaglutide and tirzepatide can lead to some muscle loss if weight is lost quickly without adequate protein intake or resistance training

Gastrointestinal side effects, including constipation, nausea, and altered bowel habits, occur frequently with these medicines

STEP 1 Trial: Adults with obesity lost an average of 14.9% of their body weight at 68 weeks with Semaglutide compared to 2.4% with placebo