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The peptide's exceptional structural stability, retained activity in gastric juice for over 24 hours, tolerance across pH 1-11, derives from its high proline content and absence of cleavage-prone motifs

To investigate mechanisms underlying FTLD-GRN, single-cell transcriptomics in the thalamus and frontal cortex of Grn / mice and FTLD-GRN patients identified a conserved astrocytic pathology marked by upregulation of GJA1, AQP4 , and Apoe , and downregulation of the glutamate transporter SLC1A2