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Tesamorelin has the strongest evidence for reducing visceral abdominal fat in adults with HIV-associated lipodystrophy, while GLP-1/GIP medications such as semaglutide and tirzepatide are generally stronger options for overall weight loss
The small increase in heart rate (23 beats per minute on average) associated with Ozempic is generally not clinically significant for most patients and does not usually require treatment modification
Mounjaro is another effective weight loss injection which is both a GLP-1 and GIP agonist that can treat both obesity and diabetes
Persistent Semaglutide fatigue may also warrant an evaluation for other underlying health conditions or the consideration of alternative treatments
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