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Bioactive tripeptides such as GHK-Cu and Lysine-Proline-Valine (KPV), including advanced formulations like KPV incorporated into in situ mucoadhesive hydrogels (KPV@PPP_E), can influence key biological events

Many previous studies have suggested that FA is the main metabolic pattern of anti-inflammatory macrophages, whereas aerobic glycolysis is considered the driving factor of pro-inflammatory states ( in vitro techniques utilizing few inflammatory stimuli (mainly LPS) or non-GA models, and are, therefore, inadequate for explaining macrophage polarization in GA (63)

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