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It behaves almost like an endocrine organ, constantly secreting inflammatory cytokines and hormones that disrupt normal metabolic function

Goutman et al., 2022

Figures 5A,D,J)

Nevertheless, these therapies are often limited by weight loss efficacy, side effects, surgical risks and frequently obesity relapse

All drugs followed a similar trend in which the calculated circulating concentration of the drug at stead state (C ss ) exhibits significant positive association with body weight loss ( Figure 1D )