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Negative symptoms include reduced tactile and thermal sensations, numbness, hypoesthesia, or anaesthesia [12]

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It may develop secondarily to HIV-induced cytokine dysregulation, to medications used in the treatment of HIV infection or HIV-associated diseases (zidovudine, clofazimine and ketoconazole), or to adrenocortical deficiency, which is not infrequent in HIV-seropositive subjects with a low CD4+ T cell counts [6, 10]

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