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doi: 10.1016/j.schres.2018.06.033 16 TandonRNasrallahHAkbarianSCarpenterWTJr.DeLisiLEGaebelWet al
2004 May 15;92(2):285-95
B12 The combination of falls and incontinence indicates an increased risk of low B12 status, and currently prescribed 2 drugs, being metformin and Somac, that are likely to exacerbate B12 depletion, therefore advisable to check B12 levels
PheWAS analysis results suggest that PNKP may affect body composition, such as muscle mass and fat metabolism, with more significant effects in females, indicating that sex differences must be considered to ensure precise and safe therapeutic outcomes
However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)
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