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In such models, persistent corticosterone (CORT) treatment, exposure to erratic moderate stressors, and social defeat are standard techniques for producing depressive-like behaviors in animals

Another report demonstrated the role of ferroptosis in the pathogenesis of mitochondrial disease-associated epilepsies and found that -tocotrienol quinone (EPI-743) potently dose-dependently ameliorated ferroptosis in the cells of patient of five distinct pediatric epilepsy syndromes by reducing LPO and 15-hydroxyeicosatetraenoic acid (15-HETE), a specific 15-LO product ( 3 )-induced posttraumatic epilepsy mouse model and in ferric ammonium citrate (FAC)-induced HT22 hippocampal neuron cells by decreasing lipid ROS and 4-HNE, downregulating prostaglandin endoperoxide synthase 2 (PTGS2), and inhibiting the expression of 12/15-lipoxygenase (12/15-LOX)

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doi: 10.1093/rheumatology/key196 122 AmatMBenjamimCFWilliamsLMPratsNTerricabrasEBeletaJet al