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Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes, the studys authors wrote

K., Feitoza, L., Hammock, B

Fumarate serves as an intermediate in the Krebs cycle, a key cellular energy-producing process

10.1007/s00125-024-06132-5 19 EngK.ZebardastN.BolandM

So even without significant weight gain, not weight, not because you're eating more or moving less, there's an increase in visceral fat being deposited

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