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Absolute contraindications to phentermine, regardless of GLP-1 status: Uncontrolled hypertension History of coronary artery disease or heart failure Uncontrolled hyperthyroidism Glaucoma History of substance use disorder (phentermine is Schedule IV) Use within 14 days of MAO inhibitors Pregnancy or planning pregnancy Age over 65 (relative contraindication) The GLP-1 alone may still be appropriate in many of these scenarios

Its also called an eye stroke

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Angling the needle increases the chance of hitting muscle tissue instead of the subcutaneous fat layer, which hurts significantly more and may affect absorption

For many people taking GLP-1 medications, shakes are useful when whole foods feel challenging, helping meet protein needs while still fitting into a balanced diet