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The NIMH-MATRICS consensus statement on negative symptoms

10.1016/j.lfs.2020.117425 19 ChenY.XiongX

It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)

An 8-day continuous subcutaneous infusion study confirmed the same

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