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Introduction Strategies to prevent or ameliorate heart failure (HF) remain urgently needed ( Within the past 2 decades, glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have emerged as effective agents to improve glycaemic control in type 2 diabetes and to reduce body weight in people with overweight or obesity ( In this article, we review current evidence suggesting a potential benefit of GLP-1 RAs in HF as well as the current understanding of the putative mechanistic underpinnings