Retatrutide also shows great potential for treating T2D in the phase 2 trial, it showed superior efficacy to dulaglutide 1.5 mg, a widely used GLP-1 RA with proven cardiovascular benefits, in reducing HbA1c and bodyweight
G., Ricci, A., Mastropasqua, F., Valentini, G., Ramunni, G., Totaro, Fila G., and Rizzon, P
This approach isnt designed for people with diabetes, who are more likely to need medication for the long term
Liposomal delivery significantly reduces this risk
These included the -opioid (Cvejic and Devi, 1997), metabotropic glutamate (Romano et al., 1996), and 2 adrenergic (Hebert et al., 1996) receptors
Another important factor was it had the capacity to bind to albumin, a large protein common in the bloodstream, which would make the GLP-1 molecule too large to be quickly cleared by the kidney