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As a matter of fact, NMDA antagonists may decrease trigeminovascular pain signal transmission in vivo (87)

I also spoke to my local Sainsburys pharmacy who told me the same thing

For people with type 2 diabetes and obesity, guidelines increasingly favor choosing GLP-1-based agents early in the treatment regimen, particularly when weight and cardiorenal risk are central goals

Understanding how semaglutide makes you feel underscores this point: the effects are metabolic and appetite-related, not psychoactive

Another factor that might explain why semaglutide causes bad breath is because less saliva being produced means the tongue isn't cleaned

While semaglutide doesn't undergo hepatic metabolism, patients with end-stage liver disease or decompensated cirrhosis may experience unpredictable drug handling and should be excluded from treatment