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Muscle preservation during caloric deficit requires a mechanical stimulus that tells the body "these muscles are being used, do not break them down for energy." Without that signal, up to 40% of weight lost can come from lean tissue rather than fat

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Trials are now under way to explore whether semaglutide could help boost rates of ovulation among those with PCOS an outcome that could also improve fertility as well as its impact on levels of hormones, including testosterone

If classified as a generic (rather than a biosimilar likely dependent on whether the drug is synthetic or recombinant), Canadian pricing regulations could require discounts of up to 75% relative to originator products, unlocking new potential for public and private payers to cover the drug at scale

The study authors caution that while their findings are promising, semaglutide should not be used off-label for tobacco addiction