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Furthermore, to address concerns related to potential immortal time bias, we performed additional sensitivity analyses, varying the time window for tirzepatide initiation to assess whether different initiation periods influenced the results, and by resetting the index date to the HFpEF diagnosis date for both groups

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In these studies, participants experienced an average loss of 15% to 21% of their initial body weight

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Comparing split dosing with other dosing strategies Split dosing is one of several non-standard approaches researchers use