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If the clinical profile is additive rather than conflicting, this becomes an interesting scientific data point - GCGR antagonism plus GIP/GLP-1 agonism recovers the diabetes-lowering benefit the antagonist era sought while preserving the incretin-driven appetite effect
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L.StrettoiE.et al (2021)
Oral semaglutide (Rybelsus) has also been approved for glycemic control in type 2 diabetes, providing a non-injectable option that supports broader patient acceptance
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