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In some cases, notably for older drugs that lost their patents years ago but still hold orphan drug exclusivity for a narrow indication, regulatory exclusivity is the only barrier remaining

(14) These emerging connections between GLP-1 signaling and skeletal physiology present a biologic rationale for how GLP-1 receptor agonists have potential to not only assist in weight management, but also favorably influence bone health and remodeling

Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I

2 For most of medicine's history, this hasn't been treated as a serious clinical concern

Caution: For external use only

Typically, healthcare providers recommend checking kidney function every 3 to 6 months, but this may vary based on individual health needs