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As an example, GSTZ1-1 catalyzes the cis-trans isomerization of 4-maleylacetoacetate to 4-fumarylacetoacetate within the phenylalanine catabolic pathway 21

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Parameters are expressed as mean S.E

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doi: 10.1016/j.cmet.2016.02.005 Maruthur NM et al (2016): Diabetes Medications as Monotherapy or Metformin-Based Combination Therapy for Type 2 Diabetes