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While medications like semaglutide focus on a single pathway that helps control appetite and blood sugar, tirzepatide activates two complementary pathways at the same time
50% of patients achieved more than 10% weight loss compared to 0% on lifestyle changes alone 23.1% of patients achieved more than 15% weight loss compared to 0% on lifestyle changes alone
The GLP-1R is expressed in many tissues, including pancreatic islets, the central nervous system, lung, kidney, heart, intestine, and also on immune cells ( When secreted by L cells, GLP-1 either functions in an endocrine manner, being released into the blood stream where it is rapidly inactivated by DPP-4 with a half-life of about 2 min, or exerts paracrine effects like stimulating neurons
13,14 AF risk reduction may be related to modification of other traditional risk factors for AF such as obesity, hypertension, atherosclerosis, 2D and obstructive sleep apnoea
It creates a surge of oxidative stress in the gut, disrupting the balance of your microbiome